Uganda Given Experimental Antibody, Antiviral Drug To Battle Ebola Outbreak

Uganda Given Experimental Antibody, Antiviral Drug To Battle Ebola Outbreak

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By Spy Uganda

The United States has sent Gilead Sciences’ (GILD.O) remdesivir and Mapp Biopharmaceutical Inc’s experimental Ebola antibody drug MBP134 to Uganda to help safeguard healthcare workers responding to an outbreak that has infected 60 people and killed 44.

There are currently no proven vaccines or treatments for the Sudan species of Ebola, one of four known Ebola viruses to cause hemorrhagic fever in humans. The outbreak confirmed by the Ugandan health ministry on Sept. 20 is the largest of the Sudan species since 2000.

Minister Jane Ruth Aceng disclosed the U.S. shipments at a meeting of African region health officials last week in Kampala and said remdesivir, which has been widely used as a COVID-19 treatment, and an undisclosed monoclonal antibody had been given to healthcare workers.

Providing treatment that protects the lives of healthcare workers could be central to containing the outbreak, said Joel Montgomery, the U.S. Centers for Disease Control and Prevention’s chief of the viral special pathogens branch and incident manager for the outbreak.
“If healthcare workers start to fall ill and die, it’s going to negatively impact the response,” said Montgomery, who had just returned from a trip to Uganda.

The World Health Organization said in a statement the agency is working with partners in Uganda to set up the infrastructure for a clinical trial and is supporting use of the untested antivirals and monoclonal antibodies and will collect data on their efficacy.

A large outbreak of the Zaire species of Ebola in West Africa from 2014-2016 led to effective vaccines and treatment, but there are no proven treatments or vaccines for the Sudan species.

San Diego-based Mapp Biopharmaceutical received a $110 million contract from the U.S. government’s Biomedical Advanced Research and Development Authority (BARDA) on Oct. 4 for advanced development and potential purchases of MBP134, a combination of monoclonal antibodies.

A study of MBP134 and remdesivir in non-human primates showed that either drug given individually rescued 20% of animals infected with the Sudan species of Ebola, but when given in combination, 80% of infected animals survived.

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